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张新科 高级实验师

 

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一、基本情况

张新科,女,博士,副高级职称,硕士生导师;

国精产品满18岁新药药理研究所,药学院新药创制筛选平台工作。

Tel:0531-88382490;

E-mail: zhangxinke@sdu.edu.cn

二、学习经历

2009/9-2012/6,山东大学,药学院生物技术研究所,博士;

2006/9-2009/6,山东大学,药学院药剂所,硕士;

2002/9-2006/6,山东大学,药学院,学士

三、工作经历

副高:2017.09-至今国精产品满18岁新药药理研究所新药筛选平台

访问学者:2018.03-2019.09美国加州大学戴维斯分校

中级:2012.07-2017.08,国精产品满18岁新药药理研究所新药筛选平台

四、研究方向

1. 纳米制剂递送给药

针对血管增生性疾病(肿瘤、糖尿病视网膜病变等),致力于研究高效穿透血脑屏障或眼球屏障的纳米靶向制剂。

2.蛋白多肽类研究

主要致力于融合蛋白的表达、纯化及活性研究;设计筛选多功能靶向穿膜肽使其用于血管增生性疾病的治疗

3. 外泌体的研究

对间充质干细胞外泌体的产量及活性评价研究。

五、承担的科研项目

1.国家自然科学基金项目,双修饰壳聚糖载TatPTD-内皮抑素基因纳米粒靶向抑制眼底血管增生的研究,立项日期2014/01

2.山东省重点研发计划,主动靶向肽A7介导的载TatPTD-内皮抑素基因壳聚糖纳米载体治疗眼部血管增生疾病的成药性研究,立项日期,2016/09。

3.山东省自然科学基金面上项目,新型穿膜双靶向肽TAT-AT7对神经胶质瘤的靶向治疗作用及机制研究 ,立项日期,2021/01

六、承担教学工作

药理学实验、临床药理学实验

七、代表性学术论文

1. Lin Zhao , Hongyuan Chen , Lu Lu , Chunqian Zhao, Christina V. Malichewe,Lei Wang , Xinke Zhang*(通讯作者) ,Xiuli Guo.Design and screening of a novel neuropilin-1 targeted penetrating peptide for anti-angiogenic therapy in glioma. Life Sciences, 2021,270,119113

2. Lin Zhao , Hongyuan Chen , Lu Lu , Lei Wang , Xinke Zhang*(通讯作者) ,Xiuli Guo. New insights into the role of co-receptor neuropilins in tumour angiogenesis and lymphangiogenesis and targeted therapy strategies.Journal of Drug Targeting. 2021,29(2):155-167

3. Lu Lu,Hongyuan Chen,Longkun Wang,Lin Zhao,Yanna Cheng,Aijun Wang,Fengshan Wang,Xinke Zhang*(通讯作者). A Dual Receptor Targeting- and BBB PenetratingPeptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma. International Journal of Nanomedicine, 2020, 15: 8875–8892.

4. Lu Lu,Chen Hongyuan,Hao Dake,Zhang Xinke*(通讯作者),Wang Fengshan. The functions and applications of A7R in anti- angiogenic therapy, imaging and drug delivery systems. Asian Journal of Pharmaceutical Sciences.2019,14(6):595-608

5. Xinke Zhang , Peng Li , Shaohua Guo , Shuqi Wang , Dasheng Liu.Quantitation ofβ-carboline and quercetin in alligator weed (Alternanthera philoxeroides (Mart.) Griseb.) by LC-MS/MS and evaluation of cardioprotective effects of the methanol extracts. Drug Discov Ther. 2018;12(6):341-346.

6. Zhang Xinke, Li Yan, Cheng Yanna, Tan Haining,Li Zhiwei, Qu Yi, Mu Guoying, Wang Fengshan. Tat PTD-endostatin: a novel anti-angiogenesis protein with ocular barrier permeability via eye-drops. BBA General Subjects, 2015;1850(6):1140-9.

7. Zhang Xinke, Zhang Xue, Wang Fengshan.Intracellular transduction and potential of Tat PTD and its analogs: from basic drug delivery mechanism to application. Expert opinion on drug delivery, 9(4):457-72, 2012.

8. Zhang XinKe, Sun Ping, Bi Ru, Wang Jinping, Zhang Na, Huang GuiHua. Targeted delivery of levofloxacin-liposomes for the treatment of pulmonary inflammation. Journal of Drug Targeting, 17(5):399–407, 2009.

9. Li Pingli , Zhang Xinke, Cheng Yanna , Li Juan , Xiao Yuliang , Zhang Qian, Zong Aizhen, Zhong Chuanqing, Wang fengshan. Preparation and in vitro immunomodulatory effect of curdlan sulfate. Carbohydrate Polymers, 2014, 102: 852– 861

10. Li Juan, Cheng Yanna, Zhang Xinke, Zheng Lei, Han Zhen, Li Pingli, Xi-ao Yuliang, Zhang Qian, Wang Fengshan. The in vivo immunomodulatory and synergistic anti-tumor activitity of thymosin α1-thymopentin fusion peptide and its binding to TLR2.Cancer Lett. 2013,337(2):237-47

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