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董婷 教授

一、基本信息:

通讯地址:济南市文化西路44号国精产品满18岁天然药物化学研究所

TEL: 0531-88382162

Email:tingdong2021@sdu.edu.cn

董婷,生物化学与分子生物学博士,国精产品满18岁教授,山东大学齐鲁青年学者。主要从事天然产物重编程巨噬细胞用于免疫代谢疾病的机制研究。迄今为止申请人累计发表学术论文13篇,含第一作者/共同第一作者论文9篇,其中影响因子10分以上期刊论文5篇(2篇Nature Communications,1篇Journal of the American Chemical Society,2篇Angewandte Chemie International Edition),参与申请国际专利2项,获得麻省理工学院博士后资助项目一项(MIT postdoctoral fellowship)。博士后期间在哈佛大学诺奖得主E. J. Corey教授实验室做短期化学生物学顾问。目前是IUBMB Life(IF=3.246)的编委,并担任多个SCI期刊的审稿人,包括PeerJ, Heliyon, Biomedicine & Phamacotherapy, Bone Research以及Internaltionl Journal of Oral Science。

二、工作以及学习经历:

学习经历:

2007年9月~20011年6月:应用化学专业,西北农林科技大学理学院,学士;

2011年9月~2016年6月:生物化学与分子生物学专业,北京生命科学研究所以及北京协和医学院联合培养,博士。

工作经历:

2016-2017:哈佛大学附属医院以及哈佛大学干细胞与组织再生生物学系,博士后;

2017-2021:麻省理工学院,博士后;

目前:国精产品满18岁教授。

三、代表性文章

1. *Li Y, *Ivica N, * Ting Dong(共一), Kleyman M, Hu G, Papageorgiou DP, He Y, Chen W, Sullivan LB. Del Rosario A, Hammond PT, Vander Heiden MG, Chen J. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Nat. commun. 2020,11, 4837.

2. Hu G, Dong T, Wang S, Jing H, and Chen J. Vitamin D3-Vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function. EBioMedicine, 2019,45,563-577.

3. Xiaohui Liu, Ting Dong(共一), Yu Zhou, Niu Huang and Xiaoguang Lei*. Exploring the Binding Proteins of Glycolipids with Bifunctional Chemical Probes. Angew. Chem. Int. Ed. 2016, 55, 14330.

4. Ting Dong(共一),Chao Li,Xing Wang, Longyang Dian, Xiuguo Zhang, Lin Li, She Chen, Ran Cao, Li Li, Niu Huang, Sudan He* & Xiaoguang Lei*. Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine. Nat. commun. 2015, 6, 6522.

5. Ting Dong, Weilong Liu, Zhirong Shen, Lin Li, She Chen & Xiaoguang Lei*. Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain. Sci. Rep. 2016, 6, 19231.

6. Ting Dong, Liao Daohong, Liu Xiaohui & Xiaoguang Lei*. Using Small Molecules to Dissect Non apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis. ChemBioChem 2015, 16, 2557.

7. Zhang Xiaoyun, Dong Ting(共一), Li Qiang, Xiaohui Liu, Xiaoying Yang & Xiaoguang Lei*. Second Generation TQ-Ligation for Cell Organelle Imaging. ACS Chem. Biol. 2015, 10, 1676.

8. Chao Li, Ting Dong(共一), Qiang Li & Xiaoguang Lei*. Probing the Anti-cancer Mechanism of (-)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation. Angew. Chem. Int. Ed. 2014. 53, 12111.

9. Qiang Li, Ting Dong(共一), Xiaohui Liu & Xiaoguang Lei*. A Bioorthogonal Ligation Enabled by Click Cycloaddition of o‑Quinolinone Quinone Methide and Vinyl Thioether. J. Am. Chem. Soc. 2013, 135, 4996. (News story describing this work was highlighted in Chem. & Eng. News. 2013, 14, 37.)

10. Qiang Li, Ting Dong, Xiaohui Liu, Xiaoyun Zhang & Xiaoguang Lei*. ortho-Quinolinone Quinone Methide Finds its Applications in the Bioorthogonal Ligation. Curr. Org. Chem. 2014, 18, 86.

11. Chao Li, Ting Dong(共一), Longyang Dian, Weidong Zhang & Xiaoguang Lei*. Biomimetic syntheses and structural elucidation of the apoptosis-inducing sesquiterpenoid trimers:(-)ainsliatrimers A and B. Chem. Sci. 2013, 4, 1163.

12. Ting Dong, Guang-Wei Wu, Xiao-Ning Wang, Jin-Ming Gao*, Jian-Guang Chen & Shoei-Sheng Lee. Microbiological transformationn of diosgenin by resting cells of filamentous fungus, Cunninghamella echinulata CGMCC 3.2716. J. Mol. Catal. B-enzym. 2010, 67, 251.

四:专利以及奖励

1. Xiaoguang Lei, Chao Li, Ting Dong. Sesquiterpenoids, US patent, 20170044180, 02-06-2017.

MIT scholar meeting(2018)

MIT scholar meeting(2019)

麻省理工博士后基金