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李连 副研究员

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李连,男,1986年10月生;博士,副研究员,制药工程学硕士研究生导师,2020年入选山东大学“未来计划”。

联系方式:E-mail:lilian@sdu.edu.cn;地址:济南市文化西路44号 国精产品满18岁,邮编250012。电话:0531-88380268。

一、研究领域

从事制药过程分析技术研究,具体方向包括:

1)基于近红外、中红外、拉曼光谱的制药过程分析技术基础理论与应用研究;

2)基于水光谱组学的生物学活性研究

二、社会兼职

中国仪器仪表学会药物质量分析与过程控制分会理事。

NIR技术服务平台专家委员会委员

三、学术成果

(一)承担课题

l 国家自然科学基金青年基金项目,具有抗补体活性硫酸软骨素的筛选及其通过调节补体系统治疗骨性关节炎的机制研究,项目负责人

l 国家重点研发计划子课题,中药生产过程可视化技术研究,子课题负责人

l 国家博士后面上基金,硫酸软骨素寡糖在类风湿性关节炎治疗中的作用机制研究,项目负责人

l 山东省博士后创新基金,项目负责人

l China–Australia Centre for Health Sciences Research (CACHSR)FUNDING,中方项目负责人

(二)代表性论文

Chen Yu, Hengchang Zang, Cui Yang, Dong Liang, Shuang Quan, Danyang Li, Yanni Li, Qin Dong, Fengshan Wang,Lian Li*. Study of chondroitin sulfate E oligosaccharide as a promising complement C5 inhibitor for osteoarthritis alleviation, Materials Science and Engineering: C, 2021,112234.

Chen Yu#, Bing Zhao#, Yan Li, Hengchang Zang,Lian Li*. Vibrational Spectroscopy in Assessment of Early Osteoarthritis—A Narrative Review. International Journal of Molecular Sciences. 2021; 22(10):5235.

Mengqi Zhang, Liang Liu, Cui Yang, Zhongyu Sun, Xiuhua Xu,Lian Li*, and Hengchang Zang*, Research on the Structure of Peanut Allergen Protein Ara h1 Based on Aquaphotomics. Frontiers in Nutrition, 2021. 8(311).

Chen Yu#, Shuang Quan#, Cui Yang, Chengliang Zhang, Jiajin Fan,Lian Li*, and Hengchang Zang*, Determination of the immunoglobulin G precipitation end-point by an intelligent near-infrared spectroscopy system. Journal of Innovative Optical Health Sciences, 2021: p. 2150007.

Lanling Liu, Kefan Zhang, Zhongyu Sun, Qin Dong,Lian Li*, and Hengchang Zang*, A new perspective in understanding the dissolution behavior of nifedipine controlled release tablets by NIR spectroscopy with aquaphotomics. Journal of Molecular Structure, 2021. 1230: p. 129872.

Lele Gao, Liang Zhong, Jin Zhang, Mengqi Zhang, Yingzi Zeng,Lian Li*, and Hengchang Zang*, Water as a probe to understand the traditional Chinese medicine extraction process with near infrared spectroscopy: A case of Danshen (Salvia miltiorrhiza Bge) extraction process. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021. 244: p. 118854.

Liang Zhong, Lele Gao,Lian Li*, Hengchang Zang*. Trends-process analytical technology in solid oral dosage manufacturing. European journal of pharmaceutics and biopharmaceuticsk,2020, (153): 187-199.

Lian Li#, Shuang Quan#, Danyang Li, Jiayue Wang, Hengchang Zang*, Lining Zhang*, Development of near infrared spectroscopy methodology for human albumin determination using a new calibration approach. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2019 (217), 56-262.

Li Lian, Li Yan, Feng Danyang, Xu Linghua, Yin Fengxin, Zang Hengchang, Liu Chunhui, Wang Fengshan*, Preparation of low molecular weight chondroitin sulfates, screening of a high anti-complement capacity of low molecular weight chondroitin sulfate and its biological activity studies in attenuating osteoarthritis, International Journal of Molecular Sciences, 2016, 17(10):1685

Li Lian, Li Yan, Ijaz Muhammad, Shahbaz Muhammad, Lian Qianqian, Wang Fengshan*, Review on complement analysis method and the roles of glycosaminoglycans in the complement system, Carbohydrate polymers, 2015, 134: 590-597

Li Lian, Zang Hengchang, Li Jun, Chen Dejun, Wang Fengshan*, Identification of anisodamine tablets by Raman and near-infrared spectroscopy with chemometrics, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 127: 91-97

Li Lian, Ding Baoyang, Yang Qi, Chen Shang, Ren Huaying, Wang Jinfeng, Zang Hengchang*, Wang Fengshan, Zang Lixuan, The relevance study of effective information between near infrared spectroscopy and chondroitin sulfate in ethanol precipitation process, Journal of Innovative Optical Health Sciences, 2014, 7(6): 1450022

(三)获奖情况

2021年,The 4th Aquaphotomics International Symposium最佳墙报奖。

2019年,国际近红外光谱学会“John Shenk Travel Awards”。

2019年,中国仪器仪表学会科技奖二等奖。

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