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张志岳 教授

一、基本情况

张志岳,博士,国精产品满18岁教授,药剂学专业博士生导师。2017年入选“山东大学齐鲁青年学者”, 截止目前,已在Angewandte Chemie International Edition(2篇), Advanced Functional Materials(3篇),Advanced Healthcare Materials(2篇),Chemistry of Materials等著名综合性期刊或药剂学领域顶级学术期刊发表SCI论文20余篇。现为中国药学会高级会员,国家公派出国留学评审专家。

通讯地址:山东省济南市文化西路44号,国精产品满18岁

电话:(86)13864186525

Email: zhiyue.zhang@sdu.edu.cn

二、研究领域

方向1:基于多功能聚合物的合成、修饰制备新型药物传递载体。

方向2:靶向修饰纳米粒作为药物传递系统的研究。

方向3:药物递送系统用于抗肿瘤免疫联合治疗

三、工作及学习经历

2018.10 -至今, 国精产品满18岁,教授、博士生导师

2016.10-2018.09,比利时根特大学(Ghent University, Belgium),博士后研究员

2012.10-2016.05,比利时根特大学(Ghent University, Belgium),博士

2009.09-2012.06,山东大学,硕士

2005.09-2009.06,山东大学,学士

四、承担课题

1、国家自然科学基金青年项目

2、国家自然科学基金委员会与欧盟委员会“中欧人才项目”

3、山东省自然科学基金青年项目

4、山东大学“齐鲁青年学者”科研启动基金;

5、中澳健康科学研究中心联合基金

五、代表性学术论文(限10篇)

1)Yanyun Hao, Hui Li, Huajun Zhao, Yutong Liu, Xiaoyan Ge, Xia Li, Hongfei Chen, Ailu Yang, Jing Zou, Xue Li, Xuechun Sun, Xinke Zhang, Xiao Wang, Zepeng Li, Qilu Zhang, Hao Wu, Guan Wang, Jian Zhang, Bruno G De Geest*,Zhiyue Zhang*. An Intelligent Nano-vehicle Armed with Multi-functional Navigation for Precise Delivery of Toll-like Receptor 7/8 Agonist and Immunogenic Cell Death Amplifiers to Eliminate Solid Tumors and Trigger Durable Antitumor Immunity.Advanced Healthcare Materials2022, DOI: 10.1002/adhm.202102739.

2) Yutong Liu†, Hui Li†, Huajun Zhao, Yanyun Hao, Simon Van Herck, Zejun Xu, Guan Wang, Xiao Wang, Xinke Zhang, Xiaoyan Ge, Xia Li, Ailu Yang, Hongfei Chen, Jing Zou, Wentao Wang, Bruno G De Geest*,Zhiyue Zhang*In Situ Tumor Vaccination with Calcium-linked Degradable Coacervate Nanocomplex Co-delivering Photosensitizer and TLR7/8 agonist to Trigger Effective Anti-tumor Immune Responses.Advanced Healthcare Materials2022, DOI: 10.1002/adhm.202102781.

3) Hui Li, Simon Van Herck, Yongjun Liu, Yanyun Hao, Xiaochu Ding, Lutz Nuhn, Zifu Zhong, Francis Combes, Niek N. Sanders, Stefan Lienenklaus, Stefaan D. Koker, Sunil A. David, Yadong Wang, Bruno G. De Geest*,Zhiyue Zhang*Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy.ACS Biomaterials Science & Engineering2020, 6, 4993–5000

4)Zhiyue Zhang, Hui Li, Sabah Kasmi, Simon Van Herck, Kim Deswarte, Bart N. Lambrecht, Richard Hoogenboom, Lutz Nuhn, Bruno G. De Geest*. A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window.Angewandte Chemie International Edition2019, 58, 7866-7872.

5)Zhiyue Zhang, Samarendra Maji, André B. da Fonseca Antunes, Riet De Rycke, Richard Hoogenboom*, Bruno G. De Geest* Salt-driven deposition of thermoresponsive polymer-coated metal nanoparticles on solid substrates.Angewandte Chemie International Edition2016, 2016, 55, 7086-7090.

6)Zhiyue Zhang, Katleen Van Steendam, Samarendra Maji, Lieve Balcaen, Yulia Anoshkina, Qilu Zhang, Glenn Vanluchene, Riet De Rycke, Frank Van Haecke, Dieter Deforce, Richard Hoogenboom*, Bruno G. De Geest* Tailoring cellular uptake of gold nanoparticles via the hydrophillic-to-hydrophobic ratio of their (co)polymer coating.Advanced Functional Materials2015, 25, 3433-3439.

7)Zhiyue Zhang†, Samarendra Maji†, André Bruno da Fonseca Antunes, Riet De Rycke, Qilu Zhang, Richard Hoogenboom*, Bruno G. De Geest* Salt Plays a Pivotal Role in the Temperature-Responsive Aggregation and Layer-by-Layer Assembly of Polymer-Decorated Gold Nanoparticles.Chemistry of Materials2013, 25, 4297-4303.

8)Z. Zhang, B. Schepens, L. Nuhn, X. Saelens, M. Schotsaert, N. Callewaert, R. De Rycke, Q. Zhang, S. Moins, S. Benali, L. Mespouille, R. Hoogenboom, B. G. De Geest* Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination.Chemical Communications2016, 52, 3352-3355.

9)Zhiyue Zhang, Nane Vanparijs, Stef Vandewalle, Filip E. Du Prez, Lutz Nuhn*, Bruno G. De Geest* Squaric ester amides as hydrolysis-resistant functional groups for protein-conjugation of RAFT-derived polymers.Polymer Chemistry2016, 7, 7242 – 7248

10) Victor R. de la Rosa,Zhiyue Zhang, Bruno G. De Geest, Richard Hoogenboom* Colorimetric Logic gates based on novel poly(2-alkyl-2-oxazoline) coated gold nanoparticles.Advanced Functional Materials2015, 25, 2511-2519.

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